Indole → HCID 19791527, compound

HRID 1655276Notes

Reaction equation

HRID 1655276 reaction equation
Cl.[CH:2]12[NH:10][CH:6]([CH2:7][CH2:8][CH2:9]1)[CH2:5][C:4](=O)[CH2:3]2.[F:12]C1C=CC(NN)=CC=1.[NH:21]1[C:29]2[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=2)C=C1>C(Cl)Cl>[F:12][N:21]1[C:29]2[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=2)[C:3]2[CH:2]3[NH:10][CH:6]([CH2:5][C:4]1=2)[CH2:7][CH2:8][CH2:9]3

Participants

5

Reactant 3

HCID 798IndoleHCID 69982(4-Fluorophenyl)hydrazineHCID 197915239-Azabicyclo[3.3.1]nonan-3-one--hydrogen chloride (1/1)

Product 1

HCID 19791527HCID 19791527, compoundYield 74%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

This compound was prepared from 9-azabicyclo[3.3.1]nonan-3-one hydrochloride and 4-fluorophenylhydrazine by the Fischer indole synthesis as described in Example 1, Method A. The product was obtained as yellow crystals (74% yield), mp 200°-201° C. (from methylene chloride).

Sources & evidence

ORD record
ord-54fda50e2a9a46aab7bda45e782e2c64
Source dataset
uspto-grants-1993_10
Patent number
US05250537

Reaction notes

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