Oxalyl chloride → (2-Methylphenoxy)acetyl chloride

HRID 1655413Notes

Reaction equation

HRID 1655413 reaction equation
[C:1]([Cl:6])(=[O:5])[C:2](Cl)=[O:3].[CH3:7][C:8]1[CH:18]=[CH:17][CH:16]=[CH:15][C:9]=1OCC(O)=O>ClCCl.CN(C)C=O>[CH3:7][C:8]1[CH:18]=[CH:17][CH:16]=[CH:15][C:9]=1[O:3][CH2:2][C:1]([Cl:6])=[O:5]

Participants

5

Reactant 2

HCID 65578Oxalyl chlorideHCID 746512-(2-Methylphenoxy)acetic acid

Product 1

HCID 12353488(2-Methylphenoxy)acetyl chloride

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideCatalystHCID 6344DichloromethaneSolvent

Procedure

Oxalyl chloride (2.2 mL, 25 mM) was added to a stirred solution of (2-methylphenoxy)acetic acid (3.32 g, 20 mM) in dichloromethane (10 mL). Dry N,N-dimethylformamide (1 drop) was added to catalyse the reaction and the mixture was stirred for 16 hours. The solvent was removed by evaporation to leave (2-methylphenoxy)acetyl chloride as a pale yellow oil, which was used without further purification.

Workup

  1. customthe reaction
  2. customThe solvent was removed by evaporation

Sources & evidence

ORD record
ord-4ddb69a8d96f4b1cac41b6fe3f40aa57
Source dataset
uspto-grants-1993_10
Patent number
US05250570

Reaction notes

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