反应详情

A mixture of methyl 4-nitro-3-valerylaminobenzoate (1.0 g), 4-(2-cyanophenyl)benzyl bromide (0.97 g) and potassium carbonate (0.55 g) in DMF (10 ml) was stirred for two days at room temperature. To the reaction mixture was added water and the mixture was extracted with ethyl acetate. The organic layer was washed with water and dried. The solvent was distilled off, and the residue was purified by column chromatography on silica gel to afford a pale yellow oil (1.24 g, 73%).

1. extractionthe mixture was extracted with ethyl acetate
2. washThe organic layer was washed with water
3. customdried
4. distillationThe solvent was distilled off
5. customthe residue was purified by column chromatography on silica gel