Phosphorus oxychloride → HCID 19792060, compound

HRID 1655573Notes

Reaction equation

HRID 1655573 reaction equation
[CH2:1]([C:5]1[N:10]=[C:9](O)[N:8]=[C:7]([C:12]([O:14][CH3:15])=[O:13])[CH:6]=1)[CH2:2][CH2:3][CH3:4].P(Cl)(Cl)([Cl:18])=O.CC1N=C(O)N=C(C(OC)=O)C=1>>[CH2:1]([C:5]1[N:10]=[C:9]([Cl:18])[N:8]=[C:7]([C:12]([O:14][CH3:15])=[O:13])[CH:6]=1)[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 3

HCID 24813Phosphorus oxychlorideHCID 178441093HCID 178441093, compoundHCID 178498184HCID 178498184, compound

Product 1

HCID 19792060HCID 19792060, compound

Procedure

Methyl 6-n-butyl-2-hydroxypyrimidine-4-carboxylate (prepared as described by Z. Budesinsky and F. Roubinek in Collection Czechoslovak Chem Commun., 26, 2871-2885 (1991)) is refluxed with phosphorous oxychloride, as described by the same authors for the chlorination of methyl 6-methyl-2-hydroxypyrimidine-4-carboxylate, to give the title compound.

Sources & evidence

ORD record
ord-40bf8f79537944cfacfe579e70100c02
Source dataset
uspto-grants-1993_10
Patent number
US05250548

Reaction notes

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