Triethylamine → HCID 178441734, compound

HRID 1655574Notes

Reaction equation

HRID 1655574 reaction equation
C(C1N=C(NCC2C=CC(C3C=CC=CC=3[C:25]3[N:29](C)[N:28]=[N:27][N:26]=3)=CC=2)C(N)=CN=1)CCC.[CH2:32]([C:36]1[N:41]=[C:40]([N:42]([CH3:61])[CH2:43][C:44]2[CH:49]=[CH:48][C:47]([C:50]3[CH:55]=[CH:54][CH:53]=[CH:52][C:51]=3C3NN=NN=3)=[CH:46][CH:45]=2)[C:39]([NH2:62])=[CH:38][N:37]=1)[CH2:33][CH2:34][CH3:35].C(N(CC)CC)C.[CH3:70][S:71](Cl)(=[O:73])=[O:72]>C(Cl)(Cl)Cl>[CH2:32]([C:36]1[N:41]=[C:40]([N:42]([CH3:61])[CH2:43][C:44]2[CH:45]=[CH:46][C:47]([C:50]3[CH:55]=[CH:54][CH:53]=[CH:52][CH:51]=3)=[C:48]([C:25]3[NH:29][N:28]=[N:27][N:26]=3)[CH:49]=2)[C:39]([NH:62][S:71]([CH3:70])(=[O:73])=[O:72])=[CH:38][N:37]=1)[CH2:33][CH2:34][CH3:35]

Participants

6

Reactant 4

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 67884770HCID 67884770, compoundHCID 178441730HCID 178441730, compound

Product 1

HCID 178441734HCID 178441734, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

2-n-Butyl-5-amino-4-{N-[N-methyl-(2'-(1H-tetrazol-5-yl]biphenyl-4-yl)methyl]amino}pyrimidine, the product of Example 46, is dissolved in chloroform containing triethylamine and treated with one equivalent of methanesulfonyl chloride to give the title compound.

Sources & evidence

ORD record
ord-3a6b6f441aa842c483492120e18502f8
Source dataset
uspto-grants-1993_10
Patent number
US05250548

Reaction notes

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