反应详情

2.5 g (10 mmol) of benzylmalonic acid diethyl ester and 1.45 ml (10 mmol) of t-butyl acrylate in 5 ml of acetonitrile were treated with 1.49 ml of DBU and stirred at room temperature for 6 hours. Thereafter, the mixture was poured into dilute hydrochloric acid (pH 2), extracted with ether, the organic phase was washed with a small amount of water, dried over sodium sulfate and the solvent was removed under reduced pressure. There were obtained 3.7 g (97%) of 4-t-butyl 2,2-diethyl 1-phenyl-2,2,4-butanetricarboxylate as a pale yellow oil which was used directly in the next step.

1. extractionextracted with ether
2. washthe organic phase was washed with a small amount of water
3. dry with materialdried over sodium sulfate
4. customthe solvent was removed under reduced pressure