Butyl iodide → HCID 21910113, compound

HRID 1655820Notes

Reaction equation

HRID 1655820 reaction equation
[C:1]([O:6][CH3:7])(=[O:5])[CH:2]([CH3:4])[OH:3].[CH2:8](I)[CH2:9][CH2:10][CH3:11]>C(OCC)(=O)C>[CH2:8]([O:3][CH:2]([CH3:4])[C:1]([O:6][CH3:7])=[O:5])[CH2:9][CH2:10][CH3:11]

Participants

4

Reactant 2

HCID 10962Butyl iodideHCID 11040Methyl Lactate

Product 1

HCID 21910113HCID 21910113, compoundYield 42.8%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Conditions

Temperature
60 °C

Procedure

20.0 g of optically active methyl lactate and 47.8 g of n-butyl iodide were dissolved in ethyl acetate, and 20 g of Ag2O and 2.0 g of Molecular Sieve 3A were added thereto, followed by 7 hours of stirring at 60° C. After filtration of the insoluble matter, the solvent was distilled off and the remainder was distilled under reduced pressure (66° C./4 mmHg) to obtain 18.4 g of the product. (Yield: 42.8 %)

Workup

  1. filtrationAfter filtration of the insoluble matter
  2. distillationthe solvent was distilled off
  3. distillationthe remainder was distilled under reduced pressure (66° C./4 mmHg)

Sources & evidence

ORD record
ord-91344ddf516a496aad0dadb3cb666e52
Source dataset
uspto-grants-1993_10
Patent number
US05252251

Reaction notes

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