Piperidin-4-ol → HCID 21618813, compound

HRID 1655857Notes

Reaction equation

HRID 1655857 reaction equation
[ClH:1].[C:2](=[NH:7])(OCC)[CH3:3].[OH:8][CH:9]1[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]1>C(O)C>[ClH:1].[NH:7]=[C:2]([N:12]1[CH2:13][CH2:14][CH:9]([OH:8])[CH2:10][CH2:11]1)[CH3:3]

Participants

4

Reactant 2

HCID 79341Piperidin-4-olHCID 2724290Ethanimidic acid, ethyl ester, hydrochloride (1:1)

Product 1

HCID 21618813HCID 21618813, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1.46 g of ethyl acetoimidate hydrochloride was added to a solution of 4-hydroxy-piperidine (1.0 g) in 10 ml of absolute ethanol. The resulting mixture was stirred at room temperature for 6 hours and then allowed to stand for 7 days. After concentration to dryness the obtained oil spontaneously solidified. After crystallization from acetone 0.7 g of the desired product were obtained. M.p. 78°-80° C.

Workup

  1. waitto stand for 7 days
  2. concentrationAfter concentration to dryness the obtained oil
  3. customAfter crystallization from acetone 0.7 g of the desired product
  4. customwere obtained

Sources & evidence

ORD record
ord-707074b987314f05a6c19427b33597dd
Source dataset
uspto-grants-1993_10
Patent number
US05252570

Reaction notes

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