Hydrochloric Acid → HCID 135625408, compound

HRID 1655860Notes

Reaction equation

HRID 1655860 reaction equation
[P:1]([CH2:5][C:6]1[CH:11]=[CH:10][N:9]2[CH:12]=[C:13]([C:15]([OH:17])=[O:16])[N:14]=[C:8]2[N:7]=1)([OH:4])([OH:3])=[O:2].Cl>[Pd].O>[P:1]([CH2:5][CH:6]1[CH2:11][CH2:10][N:9]2[CH:12]=[C:13]([C:15]([OH:17])=[O:16])[N:14]=[C:8]2[NH:7]1)([OH:3])([OH:4])=[O:2]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 15285850HCID 15285850, compound

Product 1

HCID 135625408HCID 135625408, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 962WaterSolvent

Procedure

7-phosphonomethyl-imidazo[1,2-a]pyrimidine-2-carboxylic acid 20 (8 mg) was introduced in a Parr bottle with 0.5N HCl (2 mL), water (10 mL) and Pd on Carbon (5%, 10 mg). The bottle was evacuated, filled with hydrogen (55 psi) and shaken for 1.5 hours at room temperature. The reduction mixture was then poured onto a strongly basic ion-exchange column (OH--, Amberlite). The product was eluted with IN HCl.

Workup

  1. customThe bottle was evacuated
  2. additionfilled with hydrogen (55 psi)
  3. additionThe reduction mixture was then poured onto a strongly basic ion-exchange column (OH--, Amberlite)
  4. washThe product was eluted with IN HCl

Sources & evidence

ORD record
ord-226704dbe193455e88d259d6be7b5c6d
Source dataset
uspto-grants-1993_10
Patent number
US05252563

Reaction notes

Loading…