反应详情

Dissolve N-[[1,2,3,4-tetrahydro-2-[[(t-butyl)thio]methyl]-2-naphthalenyl]carbonyl]-L-valine, benzyl ester (256 mg, 0.547 mmol) in dimethylsulfide (3 mL) and add trifluoromethanesulfonic acid (0.2 mL). Stir at room temperature under an argon atmosphere for 6 hours. Dilute with water and extract into ethyl ether. Wash with water, then brine and dry (MgSO4). Evaporate the solvent in vacuo to give the title compound.

1. extractionextract into ethyl ether
2. washWash with water
3. dry with materialbrine and dry (MgSO4)
4. customEvaporate the solvent in vacuo