Hydrochloric Acid → HCID 178501209, compound

HRID 1656053Notes

Reaction equation

HRID 1656053 reaction equation
[CH2:1]1[CH:6]2[C:7]([NH:9][CH:3]([CH2:4][CH2:5]2)[CH2:2]1)=[O:8].[ClH:10].[CH3:11][OH:12]>>[ClH:10].[NH2:9][C@@H:3]1[CH2:4][CH2:5][C@H:6]([C:7]([O:12][CH3:11])=[O:8])[CH2:1][CH2:2]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 1378872-Azabicyclo(2.2.2)octan-3-one

Product 1

HCID 178501209HCID 178501209, compound

Procedure

Dissolve 3-isoquinuclidone (1.5 g) in methanol (50 mL) and saturated with HCl. Let stand overnight then warm to reflux for 16 hours. Evaporate the solvent in vacuo to give cis-4-amino-cyclohexanecarboxylic acid, methyl ester hydrochloride as a white foam.

Workup

  1. temperaturethen warm
  2. temperatureto reflux for 16 hours
  3. customEvaporate the solvent in vacuo

Sources & evidence

ORD record
ord-ae75fc8efa694404a5a1678f1c12694e
Source dataset
uspto-grants-1993_10
Patent number
US05252601

Reaction notes

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