反应详情

Dissolve N-[[1,2,3,4-tetrahydro-2-[(acetylthio)methyl]-2-naphthalenyl]carbonyl]-isoserine, benzyl ester (4.41 g, 10.0 mmol) in deoxygenated tetrahydrofuran (50 mL). To this solution add 1N LiOH (30 mL, 30.0 mmol) and stir under an atmosphere of argon for 4 hours. Concentrate the solution in vacuo then purify the residue by column chromatography (acetic acid:ethyl acetate:hexane) to give the title compound.

1. concentrationConcentrate the solution in vacuo
2. customthen purify the residue by column chromatography (acetic acid:ethyl acetate:hexane)