Acetonitrile → HCID 9838264, compound

HRID 1656394Notes

Reaction equation

HRID 1656394 reaction equation
C(O[CH2:5][C:6]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)=O)CC.[C:14]([O:17][CH2:18][CH3:19])(=O)C.C[O-].[Na+].[C:23]([CH2:25][C:26]([NH2:28])=[O:27])#[N:24].[C:29](#N)[CH3:30]>>[C:23]([C:25]1[C:26](=[O:27])[NH:28][C:10]([C:9]2[CH:8]=[CH:6][CH:5]=[CH:19][C:18]=2[O:17][CH2:14][CH2:29][CH3:30])=[CH:11][C:12]=1[CH3:13])#[N:24]

Participants

6

Reactant 5

HCID 6342AcetonitrileHCID 7898CyanoacetamideHCID 8857Ethyl AcetateHCID 10942334Sodium MethoxideHCID 12715559HCID 12715559, compound

Product 1

HCID 9838264HCID 9838264, compound

Procedure

In a similar manner to that of Example 1, 2-propoxyacetophenone (8.9 g) was allowed to react with ethyl acetate in the presence of sodium methoxide, and the intermediate was cyclised with cyanoacetamide to give the title compound, 0.2 g, m.p. 180°-180.5° C. (from acetonitrile).

Sources & evidence

ORD record
ord-27cc893fbb66471598b38c7c3bb7a67a
Source dataset
uspto-grants-1993_10
Patent number
US05254571

Reaction notes

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