Diisobutylaluminum hydride → 7-Hydroxymethyl-2-phenyl-benzoxazole

HRID 1656682Notes

Reaction equation

HRID 1656682 reaction equation
[C:1]1([C:7]2[O:8][C:9]3[C:15]([C:16](OC)=[O:17])=[CH:14][CH:13]=[CH:12][C:10]=3[N:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.CC(C[AlH]CC(C)C)C>C1(C)C=CC=CC=1>[OH:17][CH2:16][C:15]1[C:9]2[O:8][C:7]([C:1]3[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=3)=[N:11][C:10]=2[CH:12]=[CH:13][CH:14]=1

Participants

4

Reactant 2

HCID 14487Diisobutylaluminum hydrideHCID 199399187-Benzoxazolecarboxylic acid, 2-phenyl-, methyl ester

Product 1

HCID 199399197-Hydroxymethyl-2-phenyl-benzoxazole

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent2×

Procedure

10 mmol of the compound from Example XV were dissolved in 50 ml of toluene, then 40 ml of DIBAH*(20% strength in toluene) were added at 0° C. and the mixture

Sources & evidence

ORD record
ord-f3d6f396151349c5ac4772a46dfc1bdb
Source dataset
uspto-grants-1993_10
Patent number
US05254692

Reaction notes

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