Acetic Acid → HCID 20083175, compound

HRID 1656753Notes

Reaction equation

HRID 1656753 reaction equation
[F:1][C:2]1[C:11]([F:12])=[CH:10][C:9]2[C:13](=[O:20])[C:14]([C:16]([O:18]C)=[O:17])=[CH:15][N:7]3[C:8]=2[C:3]=1[CH2:4][CH:5]([CH3:22])[N:6]3[CH3:21].Cl.C(O)(=O)C>O>[F:1][C:2]1[C:11]([F:12])=[CH:10][C:9]2[C:13](=[O:20])[C:14]([C:16]([OH:18])=[O:17])=[CH:15][N:7]3[C:8]=2[C:3]=1[CH2:4][CH:5]([CH3:22])[N:6]3[CH3:21]

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 20083173HCID 20083173, compound

Product 1

HCID 20083175HCID 20083175, compoundYield 88.1%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To 830 mg (2.7 mmol) of the compound (156) obtained in Example 34, 4 ml of concentrated hydrochloric acid and 16 ml of acetic acid were added and the solution was heated at reflux for 3 hours. 10 ml of water was added to the solution. Solids were filtered off and washed with ethanol and ether in this order to obtain 700 mg of the subject compound (157) in a 88% yield.

Workup

  1. temperaturethe solution was heated
  2. temperatureat reflux for 3 hours
  3. filtrationSolids were filtered off
  4. washwashed with ethanol and ether in this order

Sources & evidence

ORD record
ord-6b62848350114989a43dee09d98fa2ef
Source dataset
uspto-grants-1993_10
Patent number
US05254685

Reaction notes

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