Triethylamine → HCID 20083141, compound

HRID 1656757Notes

Reaction equation

HRID 1656757 reaction equation
[C:1]([C:4]1[C:5](=[O:23])[C:6]2[C:15]3[N:14]([CH:16]=1)[N:13]([CH3:17])[CH2:12][CH2:11][C:10]=3[C:9]([CH2:18]C(O)=O)=[C:8]([F:22])[CH:7]=2)([OH:3])=[O:2].C(N(CC)CC)C>C(O)C>[F:22][C:8]1[C:9]([CH3:18])=[C:10]2[C:15]3=[C:6]([C:5](=[O:23])[C:4]([C:1]([OH:3])=[O:2])=[CH:16][N:14]3[N:13]([CH3:17])[CH2:12][CH2:11]2)[CH:7]=1

Participants

4

Reactant 2

HCID 8471TriethylamineHCID 54253840HCID 54253840, compound

Product 1

HCID 20083141HCID 20083141, compoundYield 75.4%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

100 mg of the compound (163) obtained in Example 40 and 1.4 ml of triethylamine were added to 5 ml of ethanol, and the solution was heated at reflux for 15.5 hours. After air-cooling, the solids were filtered and washed successively with ethanol and ether to obtain 65 mg of the subject compound (164).

Workup

  1. temperaturethe solution was heated
  2. temperatureat reflux for 15.5 hours
  3. temperatureAfter air-cooling
  4. filtrationthe solids were filtered
  5. washwashed successively with ethanol and ether

Sources & evidence

ORD record
ord-809476f831124197b9d59366b799f45d
Source dataset
uspto-grants-1993_10
Patent number
US05254685

Reaction notes

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