Hydrochloric Acid → HCID 20083125, compound

HRID 1656765Notes

Reaction equation

HRID 1656765 reaction equation
[F:1][C:2]1[C:3]([C:21]2[CH2:26][CH2:25][CH2:24][C:23](=[O:27])[CH:22]=2)=[C:4]2[C:9]3=[C:10]([C:12](=[O:19])[C:13]([C:15]([O:17]C)=[O:16])=[CH:14][N:8]3[N:7]([CH3:20])[CH2:6][CH2:5]2)[CH:11]=1.O1CCCC1.Cl>O>[F:1][C:2]1[C:3]([C:21]2[CH2:26][CH2:25][CH2:24][C:23](=[O:27])[CH:22]=2)=[C:4]2[C:9]3=[C:10]([C:12](=[O:19])[C:13]([C:15]([OH:17])=[O:16])=[CH:14][N:8]3[N:7]([CH3:20])[CH2:6][CH2:5]2)[CH:11]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 8028TetrahydrofuranHCID 20083184HCID 20083184, compound

Product 1

HCID 20083125HCID 20083125, compoundYield 38.1%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

120 mg of the compound (171) obtained in Example 48 was added to a mixture solution of 3 ml of tetrahydrofuran, 1 ml of 6N hydrochloric acid and 1 ml of water, and the solution was stirred for four days at room temperature. The deposited solid matter was filtered off and washed with water and ethanol in this order to obtain 44 mg of the subject compound (172).

Workup

  1. filtrationThe deposited solid matter was filtered off
  2. washwashed with water and ethanol in this order

Sources & evidence

ORD record
ord-99f8d421edd344e8a6e848978dee1ec5
Source dataset
uspto-grants-1993_10
Patent number
US05254685

Reaction notes

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