Ethanol → HCID 19788688, compound

HRID 1656769Notes

Reaction equation

HRID 1656769 reaction equation
[F:1][C:2]1[C:11]([F:12])=[CH:10][C:9]2[C:13](=[O:21])[C:14]([C:16]([O:18][CH2:19][CH3:20])=[O:17])=[CH:15][N:7]3[C:8]=2[C:3]=1[CH2:4][CH2:5][N:6]3[CH2:22][OH:23].[CH2:24](N(S(F)(F)F)CC)[CH3:25].C(O)C>O1CCCC1>[F:1][C:2]1[C:11]([F:12])=[CH:10][C:9]2[C:13](=[O:21])[C:14]([C:16]([O:18][CH2:19][CH3:20])=[O:17])=[CH:15][N:7]3[C:8]=2[C:3]=1[CH2:4][CH2:5][N:6]3[CH2:22][O:23][CH2:24][CH3:25]

Participants

5

Reactant 3

HCID 702EthanolHCID 123472(Diethylamino)sulfur trifluorideHCID 20083158HCID 20083158, compound

Product 1

HCID 19788688HCID 19788688, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

65 mg of the compound (177) obtained in Example 54 was suspended in 5 ml of tetrahydrofuran, and 270 μl of diethylaminosulfurtrifluoride was added to the solution. The solution was stirred for 4 hours, and 1 ml of ethanol was added to the solution. The deposited solid matter was filtered off and washed with ether to obtain 28 mg of the subject compound (181).

Workup

  1. filtrationThe deposited solid matter was filtered off
  2. washwashed with ether

Sources & evidence

ORD record
ord-c7f0c41d26c34736ad1863408fe0207a
Source dataset
uspto-grants-1993_10
Patent number
US05254685

Reaction notes

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