Diisopropyl Ether → HCID 20083105, compound

HRID 1656777Notes

Reaction equation

HRID 1656777 reaction equation
C([O:5][C:6]([C:8]1(C(OC(C)(C)C)=O)[C:17]2[C:12]3=[C:13]([C:21](=[O:29])[C:22]([C:24]([O:26][CH2:27][CH3:28])=[O:25])=[CH:23][N:11]3[N:10]([CH3:30])[CH2:9]1)[C:14]([F:20])=[C:15]([F:19])[C:16]=2[F:18])=[O:7])(C)(C)C.C(OC(C)C)(C)C>FC(F)(F)C(O)=O>[F:18][C:16]1[C:15]([F:19])=[C:14]([F:20])[C:13]2[C:21](=[O:29])[C:22]([C:24]([O:26][CH2:27][CH3:28])=[O:25])=[CH:23][N:11]3[C:12]=2[C:17]=1[CH:8]([C:6]([OH:7])=[O:5])[CH2:9][N:10]3[CH3:30]

Participants

4

Reactant 2

HCID 7914Diisopropyl EtherHCID 20083114HCID 20083114, compound

Product 1

HCID 20083105HCID 20083105, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Conditions

Temperature
60 °C

Procedure

1.0 g of the compound (196) obtained in Example 67 was dissolved in 2 ml of trifluoroacetic acid, and the solution was heated at 60° C. for 2 hours. The reaction solution was added to 50 ml of isopropyl ether, and deposited solids were filtered off to obtain 0.67 g of the subject compound (197) in a 99% yield.

Workup

  1. filtrationwere filtered off

Sources & evidence

ORD record
ord-89338c50a3ed47d98423dc3600e966a7
Source dataset
uspto-grants-1993_10
Patent number
US05254685

Reaction notes

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