Pyrrolidine → HCID 20083096, compound

HRID 1656783Notes

Reaction equation

HRID 1656783 reaction equation
[NH2:1][C:2]1[C:11]2[C:12](=[O:18])[C:13]([C:15]([OH:17])=[O:16])=[CH:14][N:9]3[C:10]=2[C:5]([CH2:6][CH2:7][N:8]3[CH3:19])=[C:4](F)[C:3]=1[F:21].[NH:22]1[CH2:26][CH2:25][CH2:24][CH2:23]1>C(#N)C>[NH2:1][C:2]1[C:11]2[C:12](=[O:18])[C:13]([C:15]([OH:17])=[O:16])=[CH:14][N:9]3[C:10]=2[C:5]([CH2:6][CH2:7][N:8]3[CH3:19])=[C:4]([N:22]2[CH2:26][CH2:25][CH2:24][CH2:23]2)[C:3]=1[F:21]

Participants

4

Reactant 2

HCID 31268PyrrolidineHCID 20083130HCID 20083130, compound

Product 1

HCID 20083096HCID 20083096, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Conditions

Temperature
80 °C

Procedure

4 mg of the compound (202) obtained in Example 73 and 10 μl of pyrrolidine were added to 1 ml of acetonitrile, and the solution was heated at 80° C. for 3 hours. After air-cooling, the solvent was removed by distillation, and the residue was filtered off and washed with ethanol and ether in this order to obtain 2 mg of the subject compound (203).

Workup

  1. temperatureAfter air-cooling
  2. customthe solvent was removed by distillation
  3. filtrationthe residue was filtered off
  4. washwashed with ethanol and ether in this order

Sources & evidence

ORD record
ord-1404daf568254b2e82917884e5493074
Source dataset
uspto-grants-1993_10
Patent number
US05254685

Reaction notes

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