反应详情

A mixture of 4-nitrothiophenol (9.3 g), 2-amino-4-chloromethylthiazole hydrochloride (11 g) and potassium carbonate (20 g) in N,N-dimethylformamide (200 ml) was heated at 85°-90° C. for 5 hours with stirring. The reaction mixture was concentrated under reduced pressure and the residue was triturated with water. The precipitates were collected by filtration, washed with water and dried in vacuo to give 2-amino-4-[4-nitrophenylthiomethyl)thiazole (15.80 g, yield: 98.6%). IR (Nujol): 3400, 3100, 1630, 1530, 1340 cm-1

1. temperaturewas heated at 85°-90° C. for 5 hours
2. concentrationThe reaction mixture was concentrated under reduced pressure
3. customthe residue was triturated with water
4. filtrationThe precipitates were collected by filtration
5. washwashed with water
6. customdried in vacuo