反应详情

A solution of 3-chloroperbenzoic acid (4.9 g) in dichloromethane (100 ml) was dropwise added to a solution of 2-amino-4-(4-aminophenylthiomethyl)thiazole (5.1 g) in a mixture of dichloromethane (200 ml) and N,N-dimethylformamide (10 ml) at 5° C. with stirring. The mixture was stirred at 5° C. for 1.5 hours with stirring. The precipitates were collected by filtration, washed with ethyl acetate and dried in vacuo to give solid. The solid was recrystallized from ethanol to give 2-amino-4-(4-aminophenylsulfinylmethyl)thiazole (4.70 g, yield: 86.3%).

1. stirringThe mixture was stirred at 5° C. for 1.5 hours
2. stirringwith stirring
3. filtrationThe precipitates were collected by filtration
4. washwashed with ethyl acetate
5. customdried in vacuo
6. customto give solid
7. customThe solid was recrystallized from ethanol