Potassium Carbonate → HCID 15729170, compound

HRID 1656970Notes

Reaction equation

HRID 1656970 reaction equation
Cl[CH2:2][C:3]1[N:4]=[C:5]([NH:8][CH:9]=[O:10])[S:6][CH:7]=1.[N+:11]([C:14]1[CH:19]=[CH:18][C:17]([SH:20])=[CH:16][CH:15]=1)([O-:13])=[O:12].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[CH:9]([NH:8][C:5]1[S:6][CH:7]=[C:3]([CH2:2][S:20][C:17]2[CH:18]=[CH:19][C:14]([N+:11]([O-:13])=[O:12])=[CH:15][CH:16]=2)[N:4]=1)=[O:10]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 158094-NitrobenzenethiolHCID 103749692-Formylamino-4-chloromethylthiazole

Product 1

HCID 15729170HCID 15729170, compoundYield 78.2%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
100 °C

Procedure

A mixture of 4-chloromethyl-2-formylaminothiazole (1.76 g), 4-nitrothiophenol (1.7 g) and potassium carbonate (1.8 g) in N,N-dimethylformamide (20 ml) was heated at 100° C. with stirring. The reaction mixture was poured into ice-water and stirred at 5° C. for an hour. The precipitates were collected by filtration, washed with water and dried in vacuo to give 2-formylamino-4-(4-nitrophenylthiomethyl)thiazole (2.3 g, yield: 78%). mp: 158°-160° C. IR (Nujol): 3500, 1680, 1595, 1550, 1330 cm-1

Workup

  1. stirringstirred at 5° C. for an hour
  2. filtrationThe precipitates were collected by filtration
  3. washwashed with water
  4. customdried in vacuo

Sources & evidence

ORD record
ord-4a00541696b84334a7244af77dcbaf6f
Source dataset
uspto-grants-1993_10
Patent number
US05256675

Reaction notes

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