反应详情

温度

120 °C

A mixture of 2-acetylamino-5-chlorothiazole (1.76 g), 4-methoxythiophenol (1.5 g) and potassium carbonate (2.0 g) in N,N-dimethylformamide (30 ml) was heated at 120° C. for 3.5 hours with stirring. The reaction mixture was poured into ice water and the precipitates were collected by filtration to give solid. The solid was recrystallized from ethanol to give 2-acetylamino-5-(4-methoxyphenylthio)thiazole (2.2 g, Yield: 78.6%). mp: 190°-191° C. IR (Nujol): 3175, 1695, 1565, 1490, 1295, 1250 cm-1

1. filtrationthe precipitates were collected by filtration
2. customto give solid
3. customThe solid was recrystallized from ethanol