HCID 19786735, compound → HCID 57173485, compound

HRID 1657011Notes

Reaction equation

HRID 1657011 reaction equation
[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][C:7]([C:11]([NH2:13])=[O:12])=[CH:8][CH:9]=2)[C:4]([CH2:14][CH2:15][CH2:16][CH2:17][N:18]2[CH2:23][CH2:22][C:21](O)([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[CH2:20][CH2:19]2)=[CH:3]1>Cl>[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][C:7]([C:11]([NH2:13])=[O:12])=[CH:8][CH:9]=2)[C:4]([CH2:14][CH2:15][CH2:16][CH2:17][N:18]2[CH2:19][CH:20]=[C:21]([C:24]3[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=3)[CH2:22][CH2:23]2)=[CH:3]1

Participants

3

Reactant 1

HCID 19786735HCID 19786735, compound

Product 1

HCID 57173485HCID 57173485, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

4.05 g of 1-methyl-3-[4-(4-hydroxy-4-phenyl-1-piperidyl)-butyl]-indole-5-carboxamide [obtainable by reacting 1-methyl-3-(4-bromobutyl)-indole-5carboxamide with 4-piperidone, followed by reaction with C6H5Li and hydrolysis] are heated at 50° with 40 ml of hydrochloric acid for 2 hours, and the mixture is worked up in the customary manner to give 1-methyl-3-[4-(4-phenyl-1,2,3,6-tetrahydropyridyl)-butyl]-indole-5-carboxamide.

Sources & evidence

ORD record
ord-4bfc641ab3d442d8836c9c856dfc9046
Source dataset
uspto-grants-1993_10
Patent number
US05256673

Reaction notes

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