反应详情

温度

-15 °C

Construction of Benzyl-L-lactic Acid. L-Lactic acid (9 g, 100 mmol) is added to N,N'-diisopropylbenzyl-isourea (23.3 g, 100 mmol) with strirring. The mixture becomes very viscous within 10 min and is stirred intermittently for 1 h. The volume is then increased to 200 mL with THF, and the mixture stirred for 48 h at room temperature. After cooling the mixture to -15° C., the diisopropylurea is removed by filtration and the THF is evaporated under reduced pressure. The resulting thick oil is pumped under high vacuum for 24 h to give benzyl lactate (17.4 g, 95%) which may be used without further purification.

1. stirringthe mixture stirred for 48 h at room temperature
2. customthe diisopropylurea is removed by filtration
3. customthe THF is evaporated under reduced pressure
4. waitThe resulting thick oil is pumped under high vacuum for 24 h