反应详情

A mixture of 4,4-diphenyl-2-cyclopentenyl chloride (0.20 g), t-butylamine (2 ml) and a catalytic amount of sodium iodide in acetone (4 ml) was refluxed for 15 hours and cooled. The mixture was evaporated in vacuo and water was added thereto extracted with ethyl acetate. The extract was washed with brine, dried over sodium sulfate and evaporated in vacuo. The residue was purified by column chromatography on silica gel with a mixture of chloroform and methanol as an eluent to give N-t-butyl-4,4-diphenyl-2-cyclopentenylamine (0.15 g).

1. temperaturecooled
2. customThe mixture was evaporated in vacuo and water
3. additionwas added
4. extractionthereto extracted with ethyl acetate
5. washThe extract was washed with brine
6. dry with materialdried over sodium sulfate
7. customevaporated in vacuo
8. customThe residue was purified by column chromatography on silica gel with a mixture of chloroform and methanol as an eluent