Methanesulfonic Acid → N-t-butyl-3,3-diphenylcyclopentylamine methanesulfonate

HRID 1657288Notes

Reaction equation

HRID 1657288 reaction equation
[C:1]([NH:5][CH:6]1[CH2:10][CH2:9][C:8]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH2:7]1)([CH3:4])([CH3:3])[CH3:2].[CH3:23][S:24]([OH:27])(=[O:26])=[O:25]>C(Cl)(Cl)Cl.CO>[CH3:23][S:24]([OH:27])(=[O:26])=[O:25].[C:1]([NH:5][CH:6]1[CH2:10][CH2:9][C:8]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)([C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)[CH2:7]1)([CH3:4])([CH3:2])[CH3:3]

Participants

5

Reactant 2

HCID 6395Methanesulfonic AcidHCID 10379659N-t-butyl-3,3-diphenylcyclopentylamine

Product 1

HCID 19787464N-t-butyl-3,3-diphenylcyclopentylamine methanesulfonateYield 78.6%

Reagents, catalysts & solvents 2

HCID 887MethanolSolvent2×HCID 6212ChloroformSolvent

Procedure

To a solution of N-t-butyl-3,3-diphenylcyclopentylamine (0.49 g) in chloroform and methanol was added a solution of methanesulfonic acid (0.16 g) in methanol. The solvent was evaporated in vacuo and ethyl acetate was added. After standing for 2 hours, the resulting precipitate was collected to give N-t-butyl-3,3-diphenylcyclopentylamine methanesulfonate (0.51 g).

Workup

  1. customThe solvent was evaporated in vacuo and ethyl acetate
  2. additionwas added
  3. customthe resulting precipitate was collected

Sources & evidence

ORD record
ord-45f3661f9d894fc58b90de7396b5e343
Source dataset
uspto-grants-1993_10
Patent number
US05256824

Reaction notes

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