Hydrochloric Acid → HCID 54364246, compound

HRID 1657303Notes

Reaction equation

HRID 1657303 reaction equation
[CH2:1]([C:3]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[NH:5][C:4]=1[CH:12]=O)[CH3:2].[N+:14]([CH3:17])([O-:16])=[O:15].[OH-].[Na+].Cl>CO.O>[CH2:1]([C:3]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[NH:5][C:4]=1[CH:12]=[CH:17][N+:14]([O-:16])=[O:15])[CH3:2]

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 6375NitromethaneHCID 14798Sodium HydroxideHCID 12502176HCID 12502176, compound

Product 1

HCID 54364246HCID 54364246, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

To a solution of 3-ethyl-2-indolecarbaldehyde (4.0 g) and nitromethane [4.93 g) in methanol (80 ml) was added dropwise 50% aqueous sodium hydroxide solution at 0~-5° C. for an hour. After being stirred at the same temperature for an hour and at room temperature for an hour. The mixture was poured into a mixture of chilled water and 12N hydrochloric acid (4:1, 500 ml). The precipitates were collected, washed with water and dried to give 3-ethyl-2-(2-nitrovinyl)indole.

Workup

  1. customThe precipitates were collected
  2. washwashed with water
  3. customdried

Sources & evidence

ORD record
ord-8c718ac48faf45948115b94aeb3aaeab
Source dataset
uspto-grants-1993_10
Patent number
US05256780

Reaction notes

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