1,1'-Carbonyldiimidazole → HCID 10333975, compound

HRID 1657306Notes

Reaction equation

HRID 1657306 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[C:2]1[C:10]([CH3:14])([CH3:13])[CH2:11][NH2:12].[C:15](N1C=CN=C1)([N:17]1[CH:21]=[CH:20][N:19]=[CH:18]1)=[O:16]>O1CCCC1>[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[C:2]1[C:10]([CH3:14])([CH3:13])[CH2:11][NH:12][C:15]([N:17]1[CH:21]=[CH:20][N:19]=[CH:18]1)=[O:16]

Participants

4

Reactant 2

HCID 682631,1'-CarbonyldiimidazoleHCID 10465095HCID 10465095, compound

Product 1

HCID 10333975HCID 10333975, compoundYield 72.5%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of 2-(indol-2-yl)-2-methylpropylamine (363.2 mg) in tetrahydrofuran (10 ml) was added 1,1'-carbonyldiimidazole (340 mg) in small portions at room temperature. After stirring for 3 hours, the reaction mixture was evaporated in vacuo. The residue was purified by silica gel column chromatography (3% methanol-chloroform) to give N-[2-(indol-2-yl)-2-methylpropyl]-1-imidazolecarboxamide (395 mg) as crystals.

Workup

  1. customthe reaction mixture was evaporated in vacuo
  2. customThe residue was purified by silica gel column chromatography (3% methanol-chloroform)

Sources & evidence

ORD record
ord-0e4da37171c64ff1aa2b799249fa0cda
Source dataset
uspto-grants-1993_10
Patent number
US05256780

Reaction notes

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