Trifluoroacetic acid → HCID 22610268, compound

HRID 1657558Notes

Reaction equation

HRID 1657558 reaction equation
FC(F)(F)C(O)=O.[F:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2(O)[CH2:20][CH2:19][C:18](=[O:21])[CH2:17][CH2:16]2)=[CH:11][CH:10]=1.C(=O)(O)[O-].[Na+]>>[F:8][C:9]1[CH:10]=[CH:11][C:12]([C:15]2[CH2:20][CH2:19][C:18](=[O:21])[CH2:17][CH:16]=2)=[CH:13][CH:14]=1

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 516892Sodium BicarbonateHCID 223953644-(4-Fluorophenyl)-4-hydroxycyclohexan-1-one

Product 1

HCID 22610268HCID 22610268, compoundYield 96%

Procedure

To 17 ml. of well stirred trifluoroacetic acid, 0.16 g. of 4-(p-fluorophenyl)-4-hydroxycyclohexanone (obtained as in Example 3) is added. At the end of about 5 minutes the mixture is poured into an excess of aqueous sodium bicarbonate solution. The solid material is collected on a filter and recrystallized from petroleum ether to give a 96% yield of 4-(p-fluorophenyl)-3-cyclohexen-1-one melting at 44.5° to 46.5° C.

Workup

  1. customThe solid material is collected on
  2. filtrationa filter
  3. customrecrystallized from petroleum ether

Sources & evidence

ORD record
ord-bd450e97b9cf4fa1a50cb4c835ddbf87
Source dataset
uspto-grants-1976_06
Patent number
US03960961

Reaction notes

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