Imidazole → HCID 54220962, compound

HRID 1657583Notes

Reaction equation

HRID 1657583 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[C:4]([Cl:18])[N:3]=1.[NH:19]1[CH:23]=[CH:22][N:21]=[CH:20]1.C(N(CCCC)CCCC)CCC>O1CCOCC1>[Cl:18][C:4]1[N:3]=[C:2]([C:20]2[NH:19][CH:23]=[CH:22][N:21]=2)[C:11]2[C:6]([C:5]=1[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=[CH:7][CH:8]=[CH:9][CH:10]=2

Participants

5

Reactant 3

HCID 795ImidazoleHCID 7622TributylamineHCID 21534896HCID 21534896, compound

Product 1

HCID 54220962HCID 54220962, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

2.74 g (10 moles) of 1,3-dichloro-4-phenylisoquinoline, 1.02 g (15 mmoles) of imidazole and 2.7 g (15 mmoles) of tri-n-butylamine were heated for 18 hours in 5 ml of dioxane under reflux. Working was carried out as described under 1c.

Workup

  1. temperatureunder reflux

Sources & evidence

ORD record
ord-8bdf5ca1d67049fa8adbd191bbfbb49c
Source dataset
uspto-grants-1976_06
Patent number
US03961062

Reaction notes

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