1-Bromo-3-chloropropane → HCID 21534851, compound

HRID 1657594Notes

Reaction equation

HRID 1657594 reaction equation
Br[CH2:2][CH2:3][CH2:4][Cl:5].[CH3:6][O:7][C:8]1[CH:21]=[CH:20][C:19]2[S:18][C:17]3[C:12](=[CH:13][CH:14]=[CH:15][C:16]=3[S:22]([CH3:25])(=[O:24])=[O:23])[NH:11][C:10]=2[CH:9]=1.[OH-].[K+]>C(C(C)=O)C>[CH3:6][O:7][C:8]1[CH:21]=[CH:20][C:19]2[S:18][C:17]3[C:12](=[CH:13][CH:14]=[CH:15][C:16]=3[S:22]([CH3:25])(=[O:24])=[O:23])[N:11]([CH2:2][CH2:3][CH2:4][Cl:5])[C:10]=2[CH:9]=1

Participants

5

Reactant 3

HCID 80061-Bromo-3-chloropropaneHCID 14797Potassium HydroxideHCID 21534824HCID 21534824, compound

Product 1

HCID 21534851HCID 21534851, compoundYield 75.5%

Reagents, catalysts & solvents 1

HCID 6569Methyl Ethyl KetoneSolvent

Procedure

2-Methoxy-6-methylsulphonyl-10-(3-chloropropyl)phenothiazine (m.p. 122°-124°C.; 15.0 g.) is prepared by reacting 1-bromo-3-chloropropane (30.4 g.) with 2-methoxy-6-methylsulphonylphenothiazine (15.9 g.) in the presence of 85% pure ground potassium hydroxide (5.6 g.) dissolved in methyl ethyl ketone (75 cc.).

Sources & evidence

ORD record
ord-e665782cecba43519efbd5a8eed65c46
Source dataset
uspto-grants-1976_06
Patent number
US03961055

Reaction notes

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