Ethanol → HCID 68127629, compound

HRID 1657596Notes

Reaction equation

HRID 1657596 reaction equation
[CH3:1][O:2][C:3]1[CH:16]=[CH:15][C:14]2[S:13][C:12]3[C:7](O[CH:9]=[CH:10][C:11]=3[S:17]([CH3:20])(=[O:19])=[O:18])=[N:6][C:5]=2[CH:4]=1.C[O:22][C:23]1C=CC2SC3C(=CC=CC=3SC)N(C(=O)C)C=2[CH:24]=1.[CH2:42]([OH:44])C>OO>[CH3:1][O:2][C:3]1[CH:16]=[CH:15][C:14]2[S:13][C:12]3[C:11]([S:17]([CH3:20])(=[O:19])=[O:18])=[CH:10][CH2:9][C:42](=[O:44])[C:7]=3[N:6]([C:23](=[O:22])[CH3:24])[C:5]=2[CH:4]=1

Participants

5

Reactant 3

HCID 702EthanolHCID 21534832HCID 21534832, compoundHCID 21534855HCID 21534855, compound

Product 1

HCID 68127629HCID 68127629, compound

Reagents, catalysts & solvents 1

HCID 784Hydrogen PeroxideSolvent

Procedure

2-Methoxy-6-methylsulphonyl-9-oxaphenothiazine (m.p. higher than 280°C.; 48 g.) is prepared by oxidation of 2-methoxy-6-methylthio-10-acetylphenothiazine (m.p. 106°-108°C.; 55.0 g.) dissolved in 95% ethanol (95 cc.) by means of 130 volumes hydrogen peroxide (842 cc.). The crude 2-methoxy-6-methylsulphonyl-9-oxo-10-acetylphenothiazine obtained (m.p. about 160°C.) is saponified by means of an alcoholic solution of potassium hydroxide (11.2 g.) in ethanol (200 cc.).

Workup

  1. customm.p. higher than 280°C.

Sources & evidence

ORD record
ord-209565cc4d5548a2a1f8050f839f64ea
Source dataset
uspto-grants-1976_06
Patent number
US03961055

Reaction notes

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