1-Bromo-3-chloropropane → 2-Isopropoxy-6-dimethylsulphamoyl-10-(3-chloropropyl)phenothiazine

HRID 1657598Notes

Reaction equation

HRID 1657598 reaction equation
Br[CH2:2][CH2:3][CH2:4][Cl:5].[CH:6]([O:9][C:10]1[CH:23]=[CH:22][C:21]2[S:20][C:19]3[C:14](=[CH:15][CH:16]=[CH:17][C:18]=3[S:24](=[O:29])(=[O:28])[N:25]([CH3:27])[CH3:26])[NH:13][C:12]=2[CH:11]=1)([CH3:8])[CH3:7]>>[CH:6]([O:9][C:10]1[CH:23]=[CH:22][C:21]2[S:20][C:19]3[C:14](=[CH:15][CH:16]=[CH:17][C:18]=3[S:24](=[O:28])(=[O:29])[N:25]([CH3:27])[CH3:26])[N:13]([CH2:2][CH2:3][CH2:4][Cl:5])[C:12]=2[CH:11]=1)([CH3:8])[CH3:7]

Participants

3

Reactant 2

HCID 80061-Bromo-3-chloropropaneHCID 215348102-Isopropoxy-6-dimethylsulphamoylphenothiazine

Product 1

HCID 215348502-Isopropoxy-6-dimethylsulphamoyl-10-(3-chloropropyl)phenothiazineYield 96.6%

Procedure

Crude 2-isopropoxy-6-dimethylsulphamoyl-10-(3-chloropropyl)phenothiazine (60.8 g.) is prepared by reacting 1-bromo-3-chloropropane (80.8 g.) with 2-isopropoxy-6-dimethylsulphamoylphenothiazine (m.p. 187°-189°C.; 52.0 g.).

Sources & evidence

ORD record
ord-e8495bff95054db6a66bc3af4b156904
Source dataset
uspto-grants-1976_06
Patent number
US03961055

Reaction notes

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