Hydrochloric Acid → HCID 21506809, compound

HRID 1657852Notes

Reaction equation

HRID 1657852 reaction equation
[OH:1][C:2]1([C:9]2[CH:14]=[C:13]([C:15]([F:18])([F:17])[F:16])[CH:12]=[CH:11][C:10]=2[CH2:19]O)[CH2:7][CH2:6][N:5]([CH3:8])[CH2:4][CH2:3]1.Cl>>[CH3:8][N:5]1[CH2:6][CH2:7][C:2]2([C:9]3[C:10](=[CH:11][CH:12]=[C:13]([C:15]([F:17])([F:18])[F:16])[CH:14]=3)[CH2:19][O:1]2)[CH2:3][CH2:4]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 867335264-Hydroxy-4-(alpha-hydroxy-4-trifluoromethyl-2-tolyl)-1-methylpiperidine

Product 1

HCID 21506809HCID 21506809, compound

Procedure

Treatment of 4-hydroxy-4-(α-hydroxy-4-trifluoromethyl-2-tolyl)-1-methylpiperidine with hydrochloric acid by the method described in Example 16d provides 1,3-dihydro-1'-methyl-6-trifluoromethylspiro[isobenzofuran-1,4'-piperidine].

Sources & evidence

ORD record
ord-9e703be7e72b4721bfba08501dbdf5a0
Source dataset
uspto-grants-1976_06
Patent number
US03962259

Reaction notes

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