Methyl iodide → HCID 21532028, compound

HRID 1657927Notes

Reaction equation

HRID 1657927 reaction equation
[C:1]([C:3]1[C:8]([CH:9]([CH3:11])[CH3:10])=[CH:7][C:6]([CH2:12][C:13]#[N:14])=[C:5]([CH:15]([CH3:17])[CH3:16])[CH:4]=1)#[N:2].[H-].[Na+].[CH3:20]I>O1CCCC1>[C:1]([C:3]1[C:8]([CH:9]([CH3:11])[CH3:10])=[CH:7][C:6]([CH:12]([CH3:20])[C:13]#[N:14])=[C:5]([CH:15]([CH3:17])[CH3:16])[CH:4]=1)#[N:2]

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 21531233HCID 21531233, compound

Product 1

HCID 21532028HCID 21532028, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

A mixture of 4-cyano-2,5-diisopropylbenzeneacetonitrile (22.6 parts), 4.8 parts of a 50% sodium hydride suspension in mineral oil, and 14.2 parts of methyl iodide in 300 parts tetrahydrofuran is stirred and heated at 50° for two hours. The reaction mixture is cooled and the tetrahydrofuran stripped under reduced pressure. The solid is washed with pentane and water and dried to give 4-cyano-2,5-diisopropyl-α-methylbenzeneacetonitrile.

Workup

  1. temperatureheated at 50° for two hours
  2. temperatureThe reaction mixture is cooled
  3. washThe solid is washed with pentane and water
  4. customdried

Sources & evidence

ORD record
ord-7e398fd89cbf4478996b2da56ca484bd
Source dataset
uspto-grants-1976_06
Patent number
US03962307

Reaction notes

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