反应详情

温度

0 °C

p-Toluene sulfonyl chloride (1.425 g., 7.5 mm.) was added at 0°C to a solution of 1.00g. (6.95 mm.) of methyl cis 6-hydroxy-3-hexenoate in 2.37 g. of dry pyridine. The resulting mixture was stirred at 0°C for 4 hours. The crude product was poured on ice and concentrated hydrochloric acid, extracted with benzene, washed with 2N hydrochloric acid, sodium carbonate till neutral and dried over potassium carbonate. Evaporation of the solvent produced 1.425 g. (68% of theory) of crude tosylate.

1. extractionextracted with benzene
2. washwashed with 2N hydrochloric acid, sodium carbonate till neutral and
3. dry with materialdried over potassium carbonate
4. customEvaporation of the solvent
5. customproduced 1.425 g