Hydrochloric Acid → HCID 21532396, compound

HRID 1657988Notes

Reaction equation

HRID 1657988 reaction equation
[CH2:1]([O:9][P:10]([CH2:13][CH2:14][O:15]C(=O)C)([CH3:12])=[O:11])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].Cl>CO>[CH2:1]([O:9][P:10]([CH2:13][CH2:14][OH:15])([CH3:12])=[O:11])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86733542HCID 86733542, compound

Product 1

HCID 21532396HCID 21532396, compoundYield 82.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

100 g of 2-acetoxyethyl-methyl phosphinic acid n-octyl ester are heated to 65°-70°C in 200 ml of methanol containing 0.5 wt.% of HCl, while simultaneously removing by distillation a mixture of methyl acetate/methanol. After distillation under reduced pressure 70 g of 2-hydroxyethyl-methyl-phosphinic acid-n-octyl ester (b.p. 139°C/0.2 torr) are obtained, corresponding to a yield of 82.5% of the theoretical.

Workup

  1. customwhile simultaneously removing by distillation
  2. additiona mixture of methyl acetate/methanol
  3. distillationAfter distillation under reduced pressure 70 g of 2-hydroxyethyl-methyl-phosphinic acid-n-octyl ester (b.p. 139°C/0.2 torr)
  4. customare obtained, corresponding to a yield of 82.5% of the theoretical

Sources & evidence

ORD record
ord-da805b42f331459c9c4138cdef589cbd
Source dataset
uspto-grants-1976_06
Patent number
US03962378

Reaction notes

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