Potassium Iodide → HCID 12223718, compound

HRID 1658064Notes

Reaction equation

HRID 1658064 reaction equation
Cl[CH2:2][CH:3]([O:9][C:10](=[O:12])[CH3:11])[CH2:4][O:5][C:6](=[O:8])[CH3:7].[F:13][C:14]([F:35])([F:34])[C:15]1[CH:28]=[CH:27][C:26]2[S:25][C:24]3[C:19]4=[C:20]([C:29](=[O:33])[NH:30][C:31](=[O:32])[N:18]4[C:17]=2[CH:16]=1)[CH:21]=[CH:22][CH:23]=3.[H-].[Na+].[I-].[K+]>CN(C)C=O>[C:10]([O:9][CH:3]([CH2:4][O:5][C:6](=[O:8])[CH3:7])[CH2:2][N:30]1[C:29](=[O:33])[C:20]2[CH:21]=[CH:22][CH:23]=[C:24]3[S:25][C:26]4[CH:27]=[CH:28][C:15]([C:14]([F:35])([F:34])[F:13])=[CH:16][C:17]=4[N:18]([C:19]=23)[C:31]1=[O:32])(=[O:12])[CH3:11]

Participants

6

Reactant 4

HCID 4875Potassium IodideHCID 24758Sodium hydrideHCID 950201,2-Diacetoxy-3-chloropropaneHCID 1222371510-Trifluoromethyl-1H-pyrimido[5,4,3-kl]phenothiazine-1,3-(2H)-dione

Product 1

HCID 12223718HCID 12223718, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A mixture of 21.8 g. (0.112 mol.) of 3-chloro-1,2-diacetoxypropane, 28.0 g. (0.083 mol.) of 10-trifluoromethyl-1H-pyrimido[5,4,3-kl]phenothiazine-1,3(2H)-dione and 3.36 g. (0.080 mol.) of sodium hydride in 200 ml. of dry dimethylformamide was heated at 100°-110° for 40 hours in the presence of a catalytic amount of potassium iodide. The reaction mixture was filtered and the filtrate was evaporated to dryness under reduced pressure to give 2-(2,3-diacetoxypropyl)-10-trifluoromethyl-1H-pyrimido[5,4,3-kl]phenothiazine-1,3(2H)-dione.

Workup

  1. additionA mixture of 21.8 g
  2. filtrationThe reaction mixture was filtered
  3. customthe filtrate was evaporated to dryness under reduced pressure

Sources & evidence

ORD record
ord-574edea8d40a4d12ab0b28f5ebf5a28d
Source dataset
uspto-grants-1976_06
Patent number
US03962438

Reaction notes

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