Iodoethane → 2-(4'-Benzyl-piperazino)-5-oxo-6-carbethoxy-8-ethyl-5,8-dihydro-pyrido(2,3-d)pyrimidine

HRID 1658129Notes

Reaction equation

HRID 1658129 reaction equation
[CH2:1]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[N:15]=[CH:16][C:17]3[C:23]([O:24]CC)=[C:22]([C:27]([O:29][CH2:30][CH3:31])=[O:28])[CH:21]=[N:20][C:18]=3[N:19]=2)[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:32](I)[CH3:33]>>[CH2:1]([N:8]1[CH2:9][CH2:10][N:11]([C:14]2[N:15]=[CH:16][C:17]3[C:23](=[O:24])[C:22]([C:27]([O:29][CH2:30][CH3:31])=[O:28])=[CH:21][N:20]([CH2:32][CH3:33])[C:18]=3[N:19]=2)[CH2:12][CH2:13]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 6340IodoethaneHCID 21532581Ethyl 2-(4-benzyl-1-piperazinyl)-5-ethoxypyrido[2,3-d] pyrimidine-6-carboxylate

Product 1

HCID 122668082-(4'-Benzyl-piperazino)-5-oxo-6-carbethoxy-8-ethyl-5,8-dihydro-pyrido(2,3-d)pyrimidine

Procedure

Following the procedure described in Example 37 using ethyl 2-(4-benzyl-1-piperazinyl)-5-ethoxypyrido[2,3-d] pyrimidine-6-carboxylate with ethyl iodide, there is obtained the product, m.p. 151° - 153°C.

Workup

  1. customthere is obtained the product, m.p. 151° - 153°C.

Sources & evidence

ORD record
ord-0825fcae53294580be8315f70fd9c60f
Source dataset
uspto-grants-1976_06
Patent number
US03962443

Reaction notes

Loading…