Hydrochloric Acid → Benzenesulfonamide, 4-(3-cyclohexyl-2,4-dioxo-1-imidazolidinyl)-

HRID 1658232Notes

Reaction equation

HRID 1658232 reaction equation
C[O:2][C:3]([N:5]([C:16]1[CH:21]=[CH:20][C:19]([S:22](=[O:25])(=[O:24])[NH2:23])=[CH:18][CH:17]=1)[CH2:6][C:7]([NH:9][CH:10]1[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]1)=[O:8])=O.Cl>[OH-].[K+]>[S:22]([C:19]1[CH:20]=[CH:21][C:16]([N:5]2[CH2:6][C:7](=[O:8])[N:9]([CH:10]3[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]3)[C:3]2=[O:2])=[CH:17][CH:18]=1)(=[O:25])(=[O:24])[NH2:23]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21528867HCID 21528867, compound

Product 1

HCID 3050044Benzenesulfonamide, 4-(3-cyclohexyl-2,4-dioxo-1-imidazolidinyl)-Yield 74%

Reagents, catalysts & solvents 1

HCID 14797Potassium HydroxideSolvent

Procedure

2-(N-Methoxycarbonyl-4-sulphamoylphenylamino)-N-cyclohexylacetamide (3.7 g) was dissolved in hot conc. KOH (15.0 ml). The solution was cooled and acidified with conc. HCl. The mixture was heated for 30 min. on a water bath and then filtered to yield 2.5 g product, m.p. 237° - 238°C (ethanol/water

Workup

  1. temperatureThe solution was cooled
  2. temperatureThe mixture was heated for 30 min. on a water bath
  3. filtrationfiltered

Sources & evidence

ORD record
ord-9589c99114e34d4099d12e6e17974fe3
Source dataset
uspto-grants-1976_06
Patent number
US03963706

Reaction notes

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