Phenylethanolamine → HCID 53636592, compound

HRID 1658264Notes

Reaction equation

HRID 1658264 reaction equation
[NH:1]([C:5]1[NH:6][CH2:7][CH2:8][CH2:9][N:10]=1)[N+]([O-])=O.N[CH2:12][CH:13]([OH:20])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.C1(C)C(C)=CC=CC=1>O>[NH:6]1[CH2:7][CH2:8][CH2:9][N:10]=[C:5]1[NH:1][CH2:12][CH:13]([OH:20])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

Participants

5

Reactant 3

HCID 1000PhenylethanolamineHCID 7237O-XyleneHCID 412214N-(1,4,5,6-Tetrahydropyrimidin-2-yl)nitramide

Product 1

HCID 53636592HCID 53636592, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 7.2 parts of 1,4,5,6-tetrahydro-2-nitraminopyrimidine, 7.55 parts of α-(aminomethyl)benzyl alcohol and 12 parts of xylene is stirred and refluxed for 4 hours on a water-tap. The xylene is evaporated and the residue is dissolved in 20 parts of acetone. The product is crystallized at room temperature. It is filtered off and dried, yielding α-(1,4,5,6-tetrahydro-2-pyrimidinylaminomethyl)benzyl alcohol.

Workup

  1. customThe xylene is evaporated
  2. dissolutionthe residue is dissolved in 20 parts of acetone
  3. customThe product is crystallized at room temperature
  4. filtrationIt is filtered off
  5. customdried

Sources & evidence

ORD record
ord-626dce7b960c4c9e8428a5d63bdb6ae2
Source dataset
uspto-grants-1976_06
Patent number
US03963718

Reaction notes

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