O-Xylene → HCID 21510112, compound

HRID 1658266Notes

Reaction equation

HRID 1658266 reaction equation
[NH2:1][CH2:2][CH2:3][CH:4]([OH:11])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.N([C:16]1[NH:17][CH2:18][CH2:19][N:20]=1)[N+]([O-])=O.C1(C)C(C)=CC=CC=1>CC(C)CC(=O)C>[NH:20]1[CH2:19][CH2:18][N:17]=[C:16]1[NH:1][CH2:2][CH2:3][CH:4]([OH:11])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1

Participants

5

Reactant 3

HCID 7237O-XyleneHCID 1215483-Amino-1-phenylpropan-1-olHCID 4100422-Nitroamino-2-imidazoline

Product 1

HCID 21510112HCID 21510112, compound

Reagents, catalysts & solvents 1

HCID 7909Methyl Isobutyl KetoneSolvent

Procedure

A mixture of 8 parts of α-(2-aminoethyl)benzylalcohol, 6.5 parts of 2-(nitramino)-2-imidazoline and 40 parts of xylene is stirred and refluxed for 3 hours with waterseparator. The reaction mixture is cooled and the separated oily product is dissolved in 4-methyl-2-pentanone. The solvent is evaporated in vacuo, yielding α-{2-[N-(2-imidazolin-2-yl)amino]ethyl} benzylalcohol as a residue.

Workup

  1. temperaturerefluxed for 3 hours with waterseparator
  2. temperatureThe reaction mixture is cooled
  3. customThe solvent is evaporated in vacuo

Sources & evidence

ORD record
ord-8a4fd903ff8a44df81d1b4350f2168dd
Source dataset
uspto-grants-1976_06
Patent number
US03963718

Reaction notes

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