Benzaldehyde → HCID 21529043, compound

HRID 1658290Notes

Reaction equation

HRID 1658290 reaction equation
[CH:1]([N:4]([C:8]1[C:16]2[O:15][CH2:14][CH2:13][C:12]=2[CH:11]=[CH:10][CH:9]=1)[C:5]([NH2:7])=[O:6])([CH3:3])[CH3:2].[CH:17](=O)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>CS(O)(=O)=O.C1(C)C=CC=CC=1>[CH:1]([N:4]1[C:8]2[C:9](=[CH:10][CH:11]=[C:12]3[CH2:13][CH2:14][O:15][C:16]3=2)[CH:17]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[NH:7][C:5]1=[O:6])([CH3:3])[CH3:2]

Participants

5

Reactant 2

HCID 240BenzaldehydeHCID 21529034N-(2,3-Dihydro-1-benzofuran-7-yl)-N-propan-2-ylurea

Product 1

HCID 21529043HCID 21529043, compound

Reagents, catalysts & solvents 2

HCID 6395Methanesulfonic AcidCatalystHCID 1140TolueneSolvent

Procedure

A solution of 4.8 g. of 1-isopropyl-1-(2,3-dihydro-7-benzofuranyl)urea, 3.4 ml of benzaldehyde, 3 drops of methanesulfonic acid and 150 ml. of toluene is stirred and refluxed under a water separator for 18 hours. The cooled solution is washed with 150 ml. of water, dried with anhydrous magnesium sulfate, filtered and concentrated in vacuo to give an oil of 1-isopropyl-3,4,7,8-tetrahydro-4-phenyl-furo[3,2-h]quinazolin-2(1H)-one.

Workup

  1. temperaturerefluxed under a water separator for 18 hours
  2. washThe cooled solution is washed with 150 ml
  3. dry with materialof water, dried with anhydrous magnesium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-08393d6b4a0144c699c556c26d0b13da
Source dataset
uspto-grants-1976_06
Patent number
US03963717

Reaction notes

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