Acetone → 2,2,6,6-Tetramethyl-4-piperidone

HRID 1658306Notes

Reaction equation

HRID 1658306 reaction equation
[CH3:1][C:2]1[CH2:7][C:6]([CH3:9])([CH3:8])[NH:5][C:4]([CH3:11])([CH3:10])N=1.CC(C)=[O:14].Cl>CO>[CH3:10][C:4]1([CH3:11])[NH:5][C:6]([CH3:9])([CH3:8])[CH2:7][C:2](=[O:14])[CH2:1]1

Participants

5

Reactant 3

HCID 180AcetoneHCID 313Hydrochloric AcidHCID 68396Pyrimidine, 1,2,5,6-tetrahydro-2,2,4,6,6-pentamethyl-

Product 1

HCID 132202,2,6,6-Tetramethyl-4-piperidoneYield 140%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
60 °C

Procedure

A solution of 19.2 g. of acetonine in 70 g. of acetone was added with 7 g. of methanol. Then, 0.9 g. of dry gaseous hydrogen chloride was introduced therein and absorbed. The solution was sealed and heated at 60°C. for 10 hours to effect the reaction. After completion of the reaction, the reaction mixture was purified in the same manner as in Example 1 to obtain triacetonamine in a yield of 140%.

Workup

  1. customabsorbed
  2. customThe solution was sealed
  3. customthe reaction
  4. customAfter completion of the reaction
  5. customthe reaction mixture was purified in the same manner as in Example 1

Sources & evidence

ORD record
ord-c48bdf9b9e6544cc9dec85b8428b5836
Source dataset
uspto-grants-1976_06
Patent number
US03963730

Reaction notes

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