Hydrochloric Acid → HCID 21529154, compound

HRID 1658320Notes

Reaction equation

HRID 1658320 reaction equation
[CH3:1][O:2][C:3]1[CH:19]=[CH:18][C:6]([CH2:7][S:8][C:9]2[C:10]([C:15](N)=[O:16])=[N:11][CH:12]=[CH:13][CH:14]=2)=[CH:5][CH:4]=1.[OH-:20].[Na+].Cl>>[CH3:1][O:2][C:3]1[CH:19]=[CH:18][C:6]([CH2:7][S:8][C:9]2[C:10]([C:15]([OH:20])=[O:16])=[N:11][CH:12]=[CH:13][CH:14]=2)=[CH:5][CH:4]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 21529152HCID 21529152, compound

Product 1

HCID 21529154HCID 21529154, compound

Procedure

A suspension of 5 g. of 3-(p-methoxybenzylthio)-picolinamide in 50 ml. of 20% aqueous sodium hydroxide is refluxed for about 24 hours, then cooled and acidified with dilute hydrochloric acid. Filtering, washing the precipitate with water, drying and recrystallizing from methanol gives 3-(p-methoxybenzylthio)picolinic acid.

Workup

  1. additionA suspension of 5 g
  2. temperaturecooled
  3. filtrationFiltering
  4. washwashing the precipitate with water
  5. customdrying
  6. customrecrystallizing from methanol

Sources & evidence

ORD record
ord-d78ac1db06aa43feba56acf0aac5c7b4
Source dataset
uspto-grants-1976_06
Patent number
US03963733

Reaction notes

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