Ethyl Bromide → HCID 3504015, compound

HRID 1658345Notes

Reaction equation

HRID 1658345 reaction equation
C([O:3][C:4]1[C:13]2[C:8](=[CH:9][C:10]3[O:16][CH2:15][O:14][C:11]=3[CH:12]=2)[N:7]=[CH:6][C:5]=1[C:17]([O:19][CH2:20][CH3:21])=[O:18])C.[CH2:22](Br)[CH3:23]>C1(C)C=CC=CC=1>[CH2:22]([N:7]1[C:8]2[C:13](=[CH:12][C:11]3[O:14][CH2:15][O:16][C:10]=3[CH:9]=2)[C:4](=[O:3])[C:5]([C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:6]1)[CH3:23]

Participants

4

Reactant 2

HCID 6332Ethyl BromideHCID 12367717Ethyl 8-ethoxy-2H-[1,3]dioxolo[4,5-g]quinoline-7-carboxylate

Product 1

HCID 3504015HCID 3504015, compoundYield 98.6%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Conditions

Temperature
130 °C

Procedure

A mixture containing 25 ml of toluene, 5 g of ethyl 4-ethoxy-6,7-methylenedioxyquinoline-3-carboxylate and 5.67 g of ethyl bromide was placed in a sealed tube and heated at 130°C (bath temperature) for 30 hours. The reaction mixture was worked up as described in Example 9 and 4.93 g of ethyl 1-ethyl-6,7-methylenedioxy-4-quinolone-3-carboxylate was obtained.

Workup

  1. customwas placed in a sealed tube

Sources & evidence

ORD record
ord-91f6dec8dffe4e25bdf29676b5e76d4a
Source dataset
uspto-grants-1976_06
Patent number
US03963736

Reaction notes

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