HCID 21527616, compound → HCID 21527623, compound

HRID 1658487Notes

Reaction equation

HRID 1658487 reaction equation
C([N:8]([C:32]([CH3:35])([CH3:34])[CH3:33])[CH2:9][CH:10]([O:23][C:24](=[O:31])[C:25]1[CH:30]=[CH:29][CH:28]=[N:27][CH:26]=1)[CH2:11][O:12][C:13]1[CH:21]=[CH:20][CH:19]=[C:18]2[C:14]=1[CH2:15][C:16](=[O:22])[NH:17]2)C1C=CC=CC=1.[H][H]>O1CCCC1.[Pd]>[C:32]([NH:8][CH2:9][CH:10]([O:23][C:24](=[O:31])[C:25]1[CH:30]=[CH:29][CH:28]=[N:27][CH:26]=1)[CH2:11][O:12][C:13]1[CH:21]=[CH:20][CH:19]=[C:18]2[C:14]=1[CH2:15][C:16](=[O:22])[NH:17]2)([CH3:35])([CH3:33])[CH3:34]

Participants

5

Reactant 2

HCID 21527616HCID 21527616, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 21527623HCID 21527623, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolvent

Procedure

5 g of 4-[3-(N-benzyl-tert-butylamino)-2-nicotinoyloxypropoxy]oxindole are debenzylated with hydrogen in 25 cc of tetrahydrofuran, in the presence of 1 g of a palladium catalyst (10% of palladium on charcoal). The title compound is obtained, the dihydrochloride thereof having a M.P. of 215°-218°.

Sources & evidence

ORD record
ord-471c912e12c14d8ca754b683ea02fac4
Source dataset
uspto-grants-1976_06
Patent number
US03965095

Reaction notes

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