Potassium Carbonate → HCID 54465392, compound

HRID 1658496Notes

Reaction equation

HRID 1658496 reaction equation
[Cl-:1].[NH2:2][C:3]1[N:8]=[CH:7][CH:6]=[CH:5][N+:4]=1[CH2:9][O:10][C:11]1[CH:16]=[CH:15][C:14](Cl)=[CH:13][C:12]=1Br.C(=O)([O-])[O-].[K+].[K+]>[Cu].C(O)CC>[Cl:1][C:7]1[CH:6]=[CH:5][N:4]2[CH2:9][O:10][C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=3[N:2]=[C:3]2[N:8]=1

Participants

5

Reactant 2

HCID 11430Potassium CarbonateHCID 21527705HCID 21527705, compound

Product 1

HCID 54465392HCID 54465392, compoundYield 73%

Reagents, catalysts & solvents 2

HCID 23978CopperCatalystHCID 10311-PropanolSolvent

Procedure

A mixture of 14.0 g of 2-amino-1-[(2-bromo-4-chlorophenoxy)methyl]pyrimidinium chloride, 11.1 g of micronized, anhydrous potassium carbonate, 0.4 g of copper bronze, and 350 ml of anhydrous n-propanol is stirred and heated under reflux for about eight hours, filtered hot, and the deep yellow filtrate is concentrated to dryness in vacuo. Workup gives about 6.8 g of 2-chloro-6H-pyrimido[1,2-c] [1,3,5]-benzoxadiazepine.

Workup

  1. temperatureheated
  2. temperatureunder reflux for about eight hours
  3. filtrationfiltered hot
  4. concentrationthe deep yellow filtrate is concentrated to dryness in vacuo

Sources & evidence

ORD record
ord-bf8b9dc16b544df09c5cfacd592b275c
Source dataset
uspto-grants-1976_06
Patent number
US03965101

Reaction notes

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